Insulin resistance after a 3-day fast is associated with an increased capacity of skeletal muscle to oxidize lipids
Sarah J. Blackwood, Oscar Horwath, Marcus Moberg, Marjan Pontén, William Apró, Maria Ekblom, Filip J. Larsen, Abram Katz
Abstract
Whether lipid-mediated insulin resistance occurs as a result of an increased or decreased capacity of skeletal muscle to oxidize lipids has been debated. We show that a 3-day fast results in increases in circulating lipids and insulin resistance in subjects expressing a high or low proportion of type I muscle fibers. High expression of type I is associated with a higher capacity to oxidize lipids and a greater loss of insulin sensitivity after starvation.
Topics & Concepts
Internal medicineStarvationEndocrinologyInsulin resistanceSkeletal muscleInsulinInsulin sensitivityBiologyChemistryMedicineAdipose Tissue and MetabolismMuscle metabolism and nutritionExercise and Physiological Responses