Mutations in <i>rv0678</i> Confer Low-Level Resistance to Benzothiazinone DprE1 Inhibitors in Mycobacterium tuberculosis
Nicholas C. Poulton, Zachary A. Azadian, Michael A. DeJesus, Jeremy M. Rock
Abstract
Tuberculosis (TB) is the leading cause of death from any bacterial infection, causing 1.5 million deaths worldwide each year. Due to the emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) there have been significant efforts aimed at developing novel drugs to treat TB.
Topics & Concepts
BedaquilineMycobacterium tuberculosisTuberculosisDrug resistanceEffluxBiologyMutationMedicineMicrobiologyGeneticsGenePathologyTuberculosis Research and EpidemiologyCancer therapeutics and mechanismsMycobacterium research and diagnosis