The Antitumor Activity of Piplartine: A Review
Allana Brunna Sucupira Duarte, Rebeca C. Gomes, Vitória Regina V. Nunes, Juan Carlos Ramos Gonçalves, Camylla A. Correia, Ana Zulmira G. dos Santos, Damião Pergentino de Sousa
Abstract
Cancer is a worldwide health problem with high mortality in children and adults, making searching for novel bioactive compounds with potential use in cancer treatment essential. Piplartine, also known as piperlongumine, is an alkamide isolated from Piper longum Linn, with relevant therapeutic potential. Therefore, this review covered research on the antitumor activity of piplartine, and the studies reported herein confirm the antitumor properties of piplartine and highlight its possible application as an anticancer agent against various types of tumors. The evidence found serves as a reference for advancing mechanistic research on this metabolite and preparing synthetic derivatives or analogs with better antitumor activity in order to develop new drug candidates.