Phosphorus metabolism in the brain of cognitively normal midlife individuals at risk for Alzheimer's disease
Prodromos Parasoglou, Ricardo S. Osorio, Oleksandr Khegai, Zanetta Kovbasyuk, Margo Miller, Amanda Ho, Seena Dehkharghani, Thomas Wısnıewskı, Antonio Convit, Lisa Mosconi, Ryan Brown
Abstract
Background: P-MRS) and positron emission tomography (PET). Methods: P-MRS measurements in both cohorts to investigate the relationship of phosphorus metabolism with age. Results: P metabolites and pH in the AD risk group including elevated PCr/α-ATP, depressed PME/PDE, and elevated pH in the temporal cortices. Increased PCr/α-ATP throughout the brain was associated with aging. Conclusions: Phosphorus spectroscopy in the brain can be performed with high repeatability. Phosphorus metabolism varies with region and age, and is related to glucose uptake in adults at risk for AD. Phosphorus spectroscopy may be a valuable approach to study early changes in brain energetics in high-risk populations.