Combination of long-acting TRAIL and tumor cell-targeted photodynamic therapy as a novel strategy to overcome chemotherapeutic multidrug resistance and TRAIL resistance of colorectal cancer
Tianshan She, Qiuxiao Shi, Li Zhao, Yanru Feng, Hao Yang, Ze Tao, Heng Li, Jie Chen, Shisheng Wang, Yan Liang, Jingqiu Cheng, Xiaofeng Lu
Abstract
Tumor cell-targeted PDT extensively sensitizes CRC cells to TRAIL. Combination therapy of long-acting TRAIL and PDT is promising to combat CRC with both chemotherapeutic MDR and TRAIL resistance, which might be developed as a novel strategy for precision therapy of refractory CRC.
Topics & Concepts
Multiple drug resistancePhotodynamic therapyColorectal cancerMedicineCancer researchCancerChemotherapeutic drugsDrug resistanceOncologyPharmacologyInternal medicineBiologyChemistryMicrobiologyOrganic chemistryPhotodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsCancer Research and Treatments