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Regulation of translation by methylation multiplicity of 18S rRNA

Kuanqing Liu, Daniel A. Santos, Jeffrey A. Hussmann, Yun Wang, Benjamin M. Sutter, Jonathan S. Weissman, Benjamin P. Tu

2021Cell Reports31 citationsDOIOpen Access PDF

Abstract

A-bearing ribosomes, featuring a striking specificity for sulfur metabolism genes. Our work thus reveals methylation multiplicity as a mechanism to regulate translation.

Topics & Concepts

RibosomeBiologyRibosome profilingRibosomal RNAMethylationRNATranslation (biology)BiochemistryCell biologyProtein biosynthesis18S ribosomal RNAGeneticsGeneMessenger RNARNA modifications and cancerCancer-related gene regulationRNA and protein synthesis mechanisms
Regulation of translation by methylation multiplicity of 18S rRNA | Litcius