The mechanosensitive gene <i>arrestin domain containing 2</i> regulates myotube diameter with direct implications for disuse atrophy with aging
Grant R. Laskin, Ana Regina Cabrera, Nicholas P. Greene, Robert J. Tomko, Cynthia Vied, Bradley S. Gordon
Abstract
We establish Arrdc2 as a novel mechanosensitive gene highly induced in response to mechanical unloading, particularly in aged muscle. Arrdc2 induction in C2C12 myotubes is sufficient to produce thinner myotubes and a transcriptional landscape consistent with muscle atrophy and disuse.
Topics & Concepts
Mechanosensitive channelsMyogenesisC2C12Muscle atrophyCell biologyMyocyteAtrophyBiologyAnatomyNeuroscienceGeneticsReceptorIon channelMuscle Physiology and DisordersCardiomyopathy and Myosin StudiesGenetic Neurodegenerative Diseases