Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach
Vineet Kumar, Mengyue Yin, Kazuya Ishida, Laurent Salphati, Cornelis E. C. A. Hop, Christopher Rowbottom, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Zsuzsanna Nerada, Nóra Szilvásy, Scott Heyward, Jashvant D. Unadkat
Topics & Concepts
In vivoHepatocyteTransporterIn vitroOrganic anion transporter 1PharmacologyTECChemistryPharmacokineticsBiophysicsMedicineBiochemistryBiologyIonosphereAstronomyGeneBiotechnologyPhysicsDrug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesPharmacogenetics and Drug Metabolism