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Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis

Ping Liu, Xiaoji Cong, Shengjie Liao, Xinglong Jia, Xiaomin Wang, Wei Dai, Linhui Zhai, Lei Zhao, Jing Ji, Duan Ni, Zhiwei Liu, Yulu Chen, Lulu Pan, Wei Liu, Jian Zhang, Min Huang, Bin Liu, Minjia Tan

2021Cell Death and Differentiation43 citationsDOIOpen Access PDF

Topics & Concepts

PhosphorylationCell biologyCarcinogenesisBAG3MAPK/ERK pathwayUbiquitinWW domainF-box proteinDNA damageChemistryMutantBiologyUbiquitin ligaseCancer researchApoptosisAutophagyBiochemistryDNAGeneHeat shock proteins researchUbiquitin and proteasome pathwaysProtein Structure and Dynamics
Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis | Litcius