A Mycobacterium tuberculosis Effector Targets Mitochondrion, Controls Energy Metabolism, and Limits Cytochrome <i>c</i> Exit
Marianne Martin, Angelique DeVisch, Yves‐Marie Boudehen, Philippe Barthe, Claude Gutierrez, Obolbek Turapov, Talip Aydogan, Laurène Heriaud, Jérôme Gracy, Olivier Neyrolles, Galina V. Mukamolova, François Letourneur, Martin Cohen‐Gonsaud
Abstract
In this article, using a combination of techniques (bioinformatics, structural biology, and cell biology), we identified and characterized a new class of effectors present only in intracellular mycobacteria. These proteins specifically target host cell mitochondria when ectopically expressed in cells.
Topics & Concepts
EffectorMitochondrionIntracellularMycobacterium tuberculosisBiologyIntracellular parasiteTuberculosisCell biologyCell metabolismCellComputational biologyGeneticsMedicinePathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisBiochemical and Molecular Research