Copper-Catalyzed <i>anti</i>-Selective Radical 1,2-Alkylarylation of Terminal Alkynes
Jun-Bin Tang, Jun-Qian Bian, Yu-Shuai Zhang, Yong‐Feng Cheng, Han-Tao Wen, Zhang‐Long Yu, Zhong‐Liang Li, Qiang‐Shuai Gu, Guo‐Qiang Chen, Xin‐Yuan Liu
Abstract
-selective radical 1,2-alkylarylation of terminal alkynes with aryl boronic acids and alkyl bromides has been established. The reaction exhibits high compatibility with a wide range of terminal alkynes and diverse aryl boronic acids, thus providing facile access to various stereodefined trisubstituted alkenes in high yield under mild reaction conditions. Preliminary mechanistic investigations support the formation of alkyl radicals and their subsequent addition to alkynes in the reaction.
Topics & Concepts
ChemistryArylAlkylCatalysisYield (engineering)RadicalCopperTerminal (telecommunication)Combinatorial chemistryReaction conditionsOrganic chemistryTelecommunicationsComputer scienceMaterials scienceMetallurgyRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques