The Penicillin-Binding Protein PbpP Is a Sensor of β-Lactams and Is Required for Activation of the Extracytoplasmic Function σ Factor σ <sup>P</sup> in Bacillus thuringiensis
Kelsie M. Nauta, Theresa D. Ho, Craig D. Ellermeier
Abstract
The bacterial cell envelope is the target for numerous antibiotics. Many antibiotics target the synthesis of peptidoglycan, which is a central metabolic pathway essential for bacterial survival.
Topics & Concepts
PeptidoglycanPenicillin binding proteinsBacillus anthracisMicrobiologyBacterial cell structurePenicillinCell envelopeBacillus thuringiensisBacillus cereusAntibioticsBiochemistryCell wallChemistryBiologyBacteriaEscherichia coliGeneGeneticsAntibiotic Resistance in BacteriaBacterial Genetics and BiotechnologyAntibiotics Pharmacokinetics and Efficacy