Crosstalk between Exercise and Immunotherapy: Current Understanding and Future Directions
Jiwei Liu, Weici Liu, Yuan Wan, Wenjun Mao
Abstract
Accumulated evidence highlights that exercise can modulate multiple cytokines, influencing transcriptional pathways, and reprogramming certain metabolic processes, ultimately promoting antitumor immunity and enhancing the efficacy of immune checkpoint inhibitors in cancer patients. Exploring the mechanisms behind this will, for one thing, help us uncover key factors and pathways in exercise-assisted cancer immunotherapy, offering more possibilities for future treatment methods. For another, it will support the development of more personalized and effective exercise prescriptions, thereby improving the prognosis of cancer patients.
Topics & Concepts
CrosstalkImmunotherapyReprogrammingCancer immunotherapyMedicineCancer treatmentCancerBench to bedsideImmune systemBioinformaticsImmunologyBiologyInternal medicineCellEngineeringMedical physicsGeneticsElectronic engineeringCancer survivorship and careExercise and Physiological ResponsesChildhood Cancer Survivors' Quality of Life