Predicting Optimal Antimalarial Drug Combinations from a Standardized Plasmodium falciparum Humanized Mouse Model
Claudia Demarta‐Gatsi, Nicole Andenmatten, María-Belén Jiménez-Díaz, Nathalie Gobeau, Mohammed H. Cherkaoui-Rabti, Aline Fuchs, Pablo Díaz, Sandra Berja, Rebeca Sánchez, Hazel Gómez, Estíbaliz Ruiz, Paula Sainz, E. Salazar, R. Gil‐Merino, Luis Manuel Mendoza, Cristina Eguizábal, Didier Leroy, Joerg J. Moehrle, Belén Tornesi, Íñigo Angulo‐Barturen
Abstract
The development of new combinations of antimalarial drugs is urgently needed to prevent the spread of parasites resistant to drugs in clinical use and contribute to the control and eradication of malaria. In this work, we evaluated a standardized humanized mouse model of erythrocyte asexual stages of Plasmodium falciparum (PfalcHuMouse) for the selection of optimal drug combinations.
Topics & Concepts
Plasmodium falciparumMalariaDrugPharmacologyPiperaquineIn vivoPharmacokineticsPharmacodynamicsBiologyMedicineComputational biologyImmunologyArtemisininBiotechnologyMalaria Research and ControlComputational Drug Discovery MethodsMosquito-borne diseases and control