Side-by-side comparison of Notch- and C83 binding to γ-secretase in a complete membrane model at physiological temperature
Budheswar Dehury, Ning Tang, Rukmankesh Mehra, Tom L. Blundell, Kasper P. Kepp
Abstract
Distinct membrane dynamics and conformations of C83- and Notch-bound γ-secretase may aid the development of Notch-sparing treatments of Alzheimer's disease.
Topics & Concepts
ChemistryPresenilinHydrogen bondNotch signaling pathwayStereochemistryBiophysicsMolecular dynamicsHelix (gastropod)NucleophileCleavage (geology)Side chainAmyloid precursor protein secretaseRandom coilMembraneCrystallographyAmyloid precursor proteinBiochemistryCatalysisCircular dichroismBiologyMoleculeComputational chemistrySignal transductionEcologyPaleontologySnailPolymerAlzheimer's diseaseFracture (geology)DiseaseMedicineOrganic chemistryPathologyProtein Structure and DynamicsAlzheimer's disease research and treatmentsSupramolecular Self-Assembly in Materials