Epigenetics: Roles and therapeutic implications of non-coding RNA modifications in human cancers
Dawei Rong, Guangshun Sun, Fan Wu, Ye Cheng, Guoqiang Sun, Wei Jiang, Xiao Li, Yi Zhong, Liangliang Wu, Chuanyong Zhang, Weiwei Tang, Xuehao Wang
Abstract
-methyladenosine (m6A), and others. In this study, we focus on non-coding RNAs (ncRNAs) to summarize the epigenetic consequences of RNA modifications, and the pathogenesis of cancer, as diagnostic markers and therapeutic targets for cancer, as well as the mechanisms affecting the immune environment of cancer. In addition, we summarize the current status of epigenetic drugs for tumor therapy based on ncRNA modifications and the progress of bioinformatics methods in elucidating RNA modifications in recent years.
Topics & Concepts
EpigeneticsComputational biologyRNABiologyCoding (social sciences)Non-coding RNALong non-coding RNAGeneticsGeneSociologySocial scienceRNA modifications and cancerCancer-related molecular mechanisms researchRNA Research and Splicing