Cynarin alleviates acetaminophen-induced acute liver injury through the activation of Keap1/Nrf2-mediated lipid peroxidation defense <i>via</i> the AMPK/SIRT3 signaling pathway
Luying Zhao, Xiangting Zhang, Zhuofeng Chen, Yuning Lai, Jun Xu, Ruoru Zhou, Peipei Ma, Weimin Cai, Yuan Zeng, Xiao Wu, Huiya Ying, Fujun Yu
Abstract
Cyn alleviates APAP-induced ALI by activating the Keap1/Nrf2-mediated lipid peroxidation defense, and these effects are partly mediated through the activation of the AMPK/SIRT3 signaling pathway.
Topics & Concepts
AMPKSIRT3Lipid peroxidationSignal transductionChemistryAcetaminophenKEAP1Liver injuryAMP-activated protein kinaseLipid signalingOxidative stressPharmacologyMedicineAcetylationBiochemistryEnzymeProtein kinase ASirtuinGeneTranscription factorDrug-Induced Hepatotoxicity and ProtectionPharmacological Effects of Natural CompoundsChemotherapy-induced organ toxicity mitigation