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Isoquinolinone derivatives as potent CNS multi-receptor D2/5-HT1A/5-HT2A/5-HT6/5-HT7 agents: Synthesis and pharmacological evaluation

Jian Jin, Kun-Xiao Zhang, Fei Dou, Chao Hao, Yifang Zhang, Xudong Cao, Lanchang Gao, Jiaying Xiong, Xin Liu, Bi‐Feng Liu, Guisen Zhang, Yin Chen

2020European Journal of Medicinal Chemistry17 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryCatalepsyPharmacologyhERGDopamine receptor D2Behavioural despair testAntipsychoticDopamineReceptorTail suspension testAtypical antipsychoticSerotoninHaloperidolInternal medicinePsychologyBiochemistrySchizophrenia (object-oriented programming)MedicinePsychiatryPotassium channelHippocampusAntidepressantReceptor Mechanisms and SignalingNeurotransmitter Receptor Influence on BehaviorPharmacological Receptor Mechanisms and Effects
Isoquinolinone derivatives as potent CNS multi-receptor D2/5-HT1A/5-HT2A/5-HT6/5-HT7 agents: Synthesis and pharmacological evaluation | Litcius