Gastroprotective effect of Zinnia elegans extracts against ethanol-induced gastric mucosal damage through downregulation of TLR4 and inflammatory cytokines

Abstract

<ns4:p><ns4:bold>Background</ns4:bold>: One of the most common gastrointestinal diseases is gastric ulcer (GU). The ethanolic extract from the aerial part of <ns4:italic>Zinnia elegans</ns4:italic> was created to test its ability to protect the gastric mucosa from damage caused by ethanol in mice.</ns4:p><ns4:p> <ns4:bold>Method</ns4:bold>: <ns4:italic>Zinnia elegans </ns4:italic>ethanolic extract was administrated intragastrically once daily for three days. After the final intragastric dose, gastric ulcer in mice was created on the third day using 70% ethanol. The stomach tissues were extracted to assess the severity of the gastric mucosal changes.</ns4:p><ns4:p> <ns4:bold>Results</ns4:bold>: Orally administered <ns4:italic>Zinnia elegans</ns4:italic> ethanolic extract reduced the severity of stomach mucosal changes. In addition, the levels of tumor necrosis factor‐α (TNF‐α), interleukin-1B (IL‐1β), and tool-like receptor (TLR4) activity in stomach tissues were all dramatically reduced after oral administration of the extract. These findings demonstrate that the anti-inflammatory properties of <ns4:italic>Zinnia elegans</ns4:italic> ethanolic extract protect against ethanol-induced stomach mucosal damage in mice.</ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> The results of this investigation offer some support for the creation of new treatments for stomach ulcers as an alternative to treating gastric damage brought on by alcohol consumption.</ns4:p>

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