Prognostic Value of Brachial-Ankle Pulse Wave Velocity According to Subjects’ Clinical Characteristics: Data From Analysis of 10,597 Subjects
Hack‐Lyoung Kim, Kyu‐Sun Lee, Hyun Sung Joh, Woo‐Hyun Lim, Jae‐Bin Seo, Sang‐Hyun Kim, Joo‐Hee Zo, Myung‐A Kim
Abstract
Background: To make good use of the prognostic value of arterial stiffness, it is important to identify the population with the greatest benefit.In this study, we compared the prognostic value of brachial-ankle pulse wave velocity (baPWV) according to various clinical characteristics.Methods: A total of 10,597 subjects who underwent baPWV measurement (mean age, 61.4 9.5 years; female proportion, 42.5%) were retrospectively analyzed.Major adverse cardiovascular events (MACEs), defined as a composite of cardiac death, non-fatal myocardial infarction, coronary revascularization, and ischemic stroke were assessed during the clinical follow-up period.Results: In the multivariate analysis, clinical variables with more than 4,000 subjects were selected as grouping variables, which were sex (men and women), age ( 65 and < 65 years), body mass index (BMI) ( 25 and < 25 kg/m 2 ), hypertension (presence and absence), estimated glomerular filtration rate ( 90 and < 90 mL/min/1.73m 2 ), and statin use (user and non-user).During the median clinical follow-up duration of 3.58 years (interquartile range, 1.43-5.38years), there were 422 MACEs (4.0%).In total study subjects, baseline higher baPWV was associated with increased risk of MACE occurrence (hazard ratio for baPWV 1,800 cm/s compared to baPWV < 1,400 cm/s, 4.04; 95% confidence interval, 2.62-6.21;P < 0.001).The prognostic value of baPWV was statistically significant regardless of sex, age, BMI, hypertension, renal function, and statin use.Conclusion: Our results suggest that baPWV is not only effective in specific clinical situations, but can be effectively applied to predict cardiovascular prognosis in various clinical situations.