Whole-genome sequencing reveals potent therapeutic strategy for monomorphic epitheliotropic intestinal T-cell lymphoma
Dachuan Huang, Jing Quan Lim, Daryl Ming Zhe Cheah, Khalilatul Hanisah Binte Mohd Kahliab, Yurike Laurensia, Jane Wan Lu Pang, Esther Kam Yin Wong, Burton Kuan Hui Chia, Jasmine Goh, Xiyun Zhang, Jason Yongsheng Chan, Edward Kai‐Hua Chow, Soo‐Yong Tan, Soon Thye Lim, Choon Kiat Ong
Abstract
Key Points Whole genomic and transcriptomic analyses of MEITL revealed multiple potential therapeutic targets. Synergistic effects of pimozide and romidepsin are shown in a well-characterized MEITL PDX model.
Topics & Concepts
RomidepsinTranscriptomeLymphomaBiologyComputational biologyPimozideGenomeGenomic sequencingCancer researchGeneticsGeneImmunologyGene expressionHaloperidolHistone deacetylaseHistoneDopamineNeuroscienceLymphoma Diagnosis and TreatmentImmune Cell Function and InteractionChronic Lymphocytic Leukemia Research