Deciphering m<sup>6</sup>A methylation in monocyte-mediated cardiac fibrosis and monocyte-hitchhiked erythrocyte microvesicle biohybrid therapy
Jiawen Li, Wei Li, Kaifeng Hu, Yunxiang He, Guidong Gong, Qisong Liu, Yue Zhang, Kaiyu Zhou, Junling Guo, Yimin Hua, Jun Tang, Yifei Li
Abstract
A modifications of monocytes with STM2457, delivered via erythrocyte microvesicles, reduces inflammation and fibrosis, offering a promising therapeutic strategy for cardiac remodeling associated with device implantation.
Topics & Concepts
MicrovesicleMonocyteMedicineMicrovesiclesMethylationImmunologyCancer researchChemistryBiochemistrymicroRNAGeneCardiac Structural Anomalies and RepairRNA modifications and cancerPeptidase Inhibition and Analysis