Loss of ubiquitinated protein autophagy is compensated by persistent cnc/NFE2L2/Nrf2 antioxidant responses
Arindam Bhattacharjee, Adél Ürmösi, András Jipa, Levente Kovács, Péter Deák, Áron Szabó, Gábor Juhász
Abstract
Atg8a: Autophagy-related 8a; cnc: cap-n-collar; IFM: indirect flight muscle; KEAP1: kelch like ECH associated protein 1; LIR: LC3-interacting region; NFE2L2/Nrf2: NFE2 like bZIP transcription factor 2; PB1: Phox and Bem1; ref(2)P: refractory to sigma P; SAR: selective autophagy receptor; UBA: ubiquitin-associated.
Topics & Concepts
AutophagyATG8Cell biologyUbiquitinBiologyProtein aggregationKEAP1ProteasomeOxidative stressBiochemistryApoptosisGeneTranscription factorAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseMosquito-borne diseases and control