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Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of human cancer

Kazuyuki Kuramoto, Hiroyoshi Yamada, Takashi Shin, Yuki Sawada, Hidenori Azami, Tomohiro Yamada, Takeyuki Nagashima, Kei Ohnuki

2020Bioorganic & Medicinal Chemistry15 citationsDOI

Topics & Concepts

AMPKChemistryProtein kinase AActivator (genetics)Adenosine monophosphateAMP-activated protein kinaseAdenosineAdenosine diphosphatePharmacologyGlucose uptakeKinaseBiochemistryEndocrinologyInternal medicineReceptorBiologyInsulinMedicinePlatelet aggregationPlateletMetabolism, Diabetes, and CancerCancer, Hypoxia, and MetabolismBiochemical and Molecular Research
Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of human cancer | Litcius