Deletion of E184L, a Putative DIVA Target from the Pandemic Strain of African Swine Fever Virus, Produces a Reduction in Virulence and Protection against Virulent Challenge
Elizabeth Ramírez-Medina, Elizabeth A. Vuono, Ayushi Rai, Sarah Pruitt, Nallely Espinoza, Lauro Velázquez-Salinas, Sonia Pina-Pedrero, James Zhu, Fernando Rodrı́guez, Manuel V. Borca, Douglas P. Gladue
Abstract
No commercial vaccines are available to prevent African swine fever (ASF). The ASF pandemic caused by the ASF virus Georgia 2010 (ASFV-G) strain is seriously affecting pork production in a contiguous geographical area from Central Europe to East Asia.
Topics & Concepts
BiologyVirulenceVirologyDivaPandemicAfrican swine fever virusVirusStrain (injury)MicrobiologyCoronavirus disease 2019 (COVID-19)GeneGeneticsDiseaseInfectious disease (medical specialty)MedicineAnatomyPathologyAnimal Disease Management and EpidemiologyVector-Borne Animal DiseasesViral gastroenteritis research and epidemiology