Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors
Žiga Skok, Michaela Barančoková, Ondřej Benek, Cristina D. Cruz, Päivi Tammela, Tihomir Tomašič, Nace Zidar, Lucíja Peterlin Mašič, Anamarija Zega, Clare E. M. Stevenson, Julia E. A. Mundy, David M. Lawson, Anthony Maxwell, D. Kikelj, Janez Ilaš
Abstract
strain (MIC = 0.78 μM), is an important contribution for the development of novel gyrase and topoisomerase IV inhibitors in Gram-negative bacteria.
Topics & Concepts
DNA gyraseBenzothiazoleMoietyTopoisomeraseTopoisomerase IVStereochemistryChemistryEscherichia coliAntibacterial activityTernary complexEnzymeBiochemistryCombinatorial chemistryBacteriaBiologyGeneticsGeneCancer therapeutics and mechanismsBioactive Compounds and Antitumor AgentsSynthesis and Biological Evaluation