PTEN Dual Lipid- and Protein-Phosphatase Function in Tumor Progression
Anne Liu, Yan‐Yu Zhu, Weiping Chen, Glenn Merlino, Yanlin Yu
Abstract
PTEN is the second most highly mutated tumor suppressor in cancer, following only p53. The PTEN protein functions as a phosphatase with lipid- and protein-phosphatase activity. PTEN-lipid-phosphatase activity dephosphorylates PIP3 to form PIP2, and it then antagonizes PI3K and blocks the activation of AKT, while its protein-phosphatase activity dephosphorylates different protein substrates and plays various roles in tumorigenesis. Here, we review the PTEN mutations and protein-phosphatase substrates in tumorigenesis and metastasis. Our purpose is to clarify how PTEN protein phosphatase contributes to its tumor-suppressive functions through PI3K-independent activities.
Topics & Concepts
PTENPhosphataseCarcinogenesisSuppressorTensinProtein phosphatase 2Protein kinase BCancer researchPI3K/AKT/mTOR pathwayDual-specificity phosphatasePhosphorylationBiologyChemistryCell biologyCancerSignal transductionGeneticsPI3K/AKT/mTOR signaling in cancerCytokine Signaling Pathways and InteractionsProtein Kinase Regulation and GTPase Signaling