Pharyngeal Microbial Signatures Are Predictive of the Risk of Fungal Pneumonia in Hematologic Patients
Claudio Costantini, Emilia Nunzi, Angelica Spolzino, Melissa Palmieri, Giorgia Renga, Teresa Zelante, Lukas Englmaier, Kateřina Coufalíková, Zdeněk Spáčil, Monica Borghi, Marina Maria Bellet, Enzo Acerbi, Matteo Puccetti, Stefano Giovagnoli, Roberta Spaccapelo, Vincenzo Nicola Talesa, Giuseppe Lomurno, Francesco Merli, Luca Facchini, Antonio Spadea, Lorella Melillo, Katia Codeluppi, Francesco Marchesi, Gessica Marchesini, Daniela Valente, Giulia Dragonetti, Gianpaolo Nadali, Livio Pagano, Franco Aversa, Luigina Romani
Abstract
The ability to predict invasive fungal infections (IFI) in patients with hematological malignancies is fundamental for successful therapy. Although gut dysbiosis is known to occur in hematological patients, whether airway dysbiosis also contributes to the risk of IFI has not been investigated.