Macrophage Extracellular Traps: Current Opinions and the State of Research regarding Various Diseases
Weizhen Weng, Zuoyu Hu, Yunfeng Pan
Abstract
Macrophages are an important component of the human immune system and play a key role in the immune response, which can protect the body against infection and regulate the development of tissue inflammation. Some studies found that macrophages can produce extracellular traps (ETs) under various conditions of stimulation. ETs are web-like structures that consist of proteins and DNA. ETs are thought to immobilize and kill microorganisms, as well as play an important role in tissue damage, inflammatory progression, and autoimmune diseases. In this review, the structure, identification, mechanism, and research progress of macrophage extracellular traps (METs) in related diseases are reviewed.
Topics & Concepts
ExtracellularMacrophageInflammationImmune systemCell biologyBiologyImmunologyMechanism (biology)GeneticsIn vitroPhilosophyEpistemologyNeutrophil, Myeloperoxidase and Oxidative MechanismsAdvanced Nanomaterials in CatalysisImmune cells in cancer