Human-relevant mechanisms and risk factors for TAK-875-Induced liver injury identified via a gene pathway-based approach in Collaborative Cross mice
Merrie Mosedale, Yanwei Cai, J. Scott Eaddy, Patrick Kirby, Francis S. Wolenski, Yvonne P. Dragan, William Valdar
Topics & Concepts
Liver injuryOxidative stressBiologyToxicityPhenotypeHepatocyteGeneGenetic predispositionHomeostasisGene expression profilingImmune systemPharmacologyGene expressionBioinformaticsGeneticsMedicineInternal medicineEndocrinologyIn vitroDrug-Induced Hepatotoxicity and ProtectionPharmacogenetics and Drug MetabolismComputational Drug Discovery Methods