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Isorhapontigenin delays senescence and matrix degradation of nucleus pulposus cells via PI3K/AKT/mTOR-mediated autophagy pathway in vitro and alleviates intervertebral disc degeneration in vivo

Ze Wang, Jiawei Ma, Yun Sun, Zebin Jin, Rukang Zheng, Yuanyuan Li, Heng Yu, Haobo Ye, Yaosen Wu, Xinjiang Ge, Zexin Chen

2024International Immunopharmacology18 citationsDOI

Topics & Concepts

AutophagyPI3K/AKT/mTOR pathwayIn vivoIn vitroIntervertebral discCell biologyDegeneration (medical)Protein kinase BSenescenceNucleusMatrix (chemical analysis)ChemistryCancer researchSignal transductionPathologyMedicineBiologyAnatomyApoptosisBiochemistryGeneticsChromatographySpine and Intervertebral Disc PathologySpinal Hematomas and ComplicationsSpinal Cord Injury Research
Isorhapontigenin delays senescence and matrix degradation of nucleus pulposus cells via PI3K/AKT/mTOR-mediated autophagy pathway in vitro and alleviates intervertebral disc degeneration in vivo | Litcius