Targeting the innate immune receptor TLR8 using small-molecule agents
Kentaro Sakaniwa, Toshiyuki Shimizu
Abstract
Toll-like receptors (TLRs) are pattern-recognition receptors that initiate innate immune responses. Among the TLRs, TLR8 (and TLR7) recognizes single-stranded RNA to mediate downstream signals. In recent years, intensive X-ray crystal structural analyses have provided atomic insights into structures of TLR8 complexed with various agonists or antagonists. Here, structural knowledge of the activation and inactivation mechanisms of the ligands is reviewed. In addition, the potential clinical applications of TLR ligands are examined.
Topics & Concepts
Innate immune systemTLR7ReceptorPattern recognition receptorImmune systemToll-like receptorCell biologyBiologyComputational biologyChemistryImmunologyBiochemistryImmune Response and InflammationAntimicrobial Peptides and ActivitiesNF-κB Signaling Pathways