Four new polyynes from <i>Codonopsis pilosula</i> collected in Yunnan province, China
Jinsong Su, Fu‐Ying Qin, Ying Liu, Yi Zhang
Abstract
Choushenpilosulynes D–G (1-4): four new polyynes were isolated from the roots of Codonopsis pilosula (Campanulaceae) cultivated in Yunnan province, China. Their structures were identified by spectroscopic methods. Bioactive evaluation showed that choushenpilosulynes E (2) and F (3) demonstrated potent inhibitory effect on lipid formation induced by 100 μM oleic acid stimulation. In addition, choushenpilosulyne F (3) uncovered inhibitory activity against the expression of human 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and squalene monooxygenase (SQLE) gene transcript in HepG2 cells.
Topics & Concepts
SqualeneCodonopsisTraditional medicineBiologyOleic acidBiochemistryChemistryBotanyTraditional Chinese medicineMedicinePathologyAlternative medicinePlant biochemistry and biosynthesisNatural product bioactivities and synthesisAntioxidant Activity and Oxidative Stress