Response and Resistance to Menin Inhibitor in <i>UBTF</i> –Tandem Duplication AML
Ing Soo Tiong, David S. Ritchie, Piers Blombery
Abstract
Tandem duplication in UBTF is associated with a resistant form of AML. A menin inhibitor induced a short-lived response. Resistance was associated with mutations at the drug-binding site in MEN1, which encodes menin 1.
Topics & Concepts
MEN1Gene duplicationTandem exon duplicationCancer researchDrug resistanceBiologyGeneticsGeneMultiple endocrine neoplasiaChromatin Remodeling and CancerProtein Degradation and InhibitorsAdvanced biosensing and bioanalysis techniques