NEW DRUGS ON THE PHARMACEUTICAL MARKET CONTAINING FLUORINE AND RESIDUES OF TAILOR-MADE AMINO ACIDS
Jianlin Han, Alicja Wzorek, Gagan Dhawan, Wei Zhang, Alexander E. Sorochinsky, Daniel Baecker, Taizo Ono, Karel D. Klika, Vadim A. Soloshonok
Abstract
This article profiles five newly drugs containing fluorine along with fragments of amino acids or their derivatives approved by the FDA in 2024. These pharmaceuticals include Voydeya® (danicopan), Ojemda® (tovorafenib), Itovebi® (inavolisib), Scemblix® (asciminib), and Revuforj® (revumenib). For each drug, we discuss the discovery, therapeutic areas of application, and detailed chemical synthesis.
Topics & Concepts
ChemistryFluorineBiochemical engineeringOrganic chemistryCombinatorial chemistryPolymer scienceEngineeringFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsSynthesis and Reactions of Organic Compounds