Catalytic Ynone–Amidine Formal [4 + 2]-Cycloaddition for the Regioselective Synthesis of Tricyclic Azepines
T. Prabhakar Reddy, Jagjeet Gujral, Pritam Roy, Dhevalapally B. Ramachary
Abstract
- and self-promoted ynone-amidine atom-economic formal [4 + 2]-cycloaddition of various ynones with amidines is reported for the construction of highly functionalized tricyclic azepines. High reaction rate, ease of operation, and high product selectivity with wide substrate scope are the key advantages of the present annulation protocol.
Topics & Concepts
ChemistryCycloadditionAmidineRegioselectivityAnnulationTricyclicCatalysisCombinatorial chemistrySelectivitySubstrate (aquarium)Medicinal chemistryStereochemistryOrganic chemistryOceanographyGeologyOxidative Organic Chemistry ReactionsCatalytic Alkyne ReactionsCatalytic C–H Functionalization Methods