Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming
Geoffrey Schiebinger, Jian Shu, Marcin Tabaka, Brian Cleary, Vidya Subramanian, Aryeh Solomon, Joshua Gould, Siyan Liu, Stacie Lin, Peter Berube, Lia Lee, Jenny Chen, Justin Brumbaugh, Philippe Rigollet, Konrad Hochedlinger, Rudolf Jaenisch, Aviv Regev, Eric S. Lander
Topics & Concepts
BiologyReprogrammingEmbryonic stem cellTranscription factorCell fate determinationParacrine signallingComputational biologyInduced pluripotent stem cellDevelopmental biologyGene regulatory networkCellular differentiationGeneticsCell biologyGeneEvolutionary biologyGene expressionReceptorSingle-cell and spatial transcriptomicsPluripotent Stem Cells ResearchCRISPR and Genetic Engineering