CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas
Kylee J. Veazey, Donghang Cheng, Kevin Lin, Oscar D. Villarreal, Guozhen Gao, Mabel Pérez‐Oquendo, Hieu T. Van, Sabrina A. Stratton, Michael R. Green, Han Xu, Yue Lu, Mark T. Bedford, Margarida A. Santos
Topics & Concepts
Histone acetyltransferaseBiologySynthetic lethalityCancer researchCREB-binding proteinAcetyltransferaseMutationHistoneMolecular biologyGeneAcetylationGeneticsDNA repairTranscription factorCREBCancer-related gene regulationEpigenetics and DNA MethylationProtein Degradation and Inhibitors