Acute Immune Thrombocytopenia (ITP) Following COVID-19 Vaccination in a Patient With Previously Stable ITP
Muzamil Jawed, Amna Khalid, Mayer Rubin, Ramsha Shafiq, Nail Cemalovic
Abstract
Immune thrombocytopenia (ITP) is an autoimmune condition associated with multiple risk factors including viral infections (hepatitis B virus/hepatitis C virus/cytomegalovirus, HIV, and recently severe acute respiratory syndrome coronavirus 2) and vaccines. Though immune mechanisms have been proposed to explain the pathogenesis of acute ITP, autoimmunity with the coronavirus disease 2019 (COVID-19) vaccine is still unclear and needs further research. We report a case of acute ITP after administration of the Pfizer-BioNTech mRNA COVID-19 vaccine in a patient with previously stable ITP.
Topics & Concepts
MedicineImmunologyVaccinationImmune thrombocytopeniaCytomegalovirusImmune systemVirusCoronavirusAutoimmunityVirologyCoronavirus disease 2019 (COVID-19)Viral diseaseDiseaseAntibodyInfectious disease (medical specialty)HerpesviridaeInternal medicinePlatelet Disorders and TreatmentsBlood groups and transfusionHeparin-Induced Thrombocytopenia and Thrombosis