A 1,4‐Palladium Migration/Heck Sequence with Unactivated Alkenes: Stereoselective Synthesis of Trisubstituted 1,3‐Dienes
Ze‐Jian Xue, Mengyao Li, Bin‐Bin Zhu, Zhi‐Tao He, Chen‐Guo Feng, Guo‐Qiang Lin
Abstract
Abstract The palladium‐catalyzed cross‐coupling of ortho ‐vinyl aromatic bromides and olefins was achieved through a controllable 1,4‐palladium migration/Heck cascade protocol. The reaction represents a mild, efficient and highly stereoselective method for the synthesis of trisubstituted 1,3‐dienes, especially for triaryl‐substituted ones. magnified image
Topics & Concepts
ChemistryStereoselectivityPalladiumHeck reactionOrganic chemistrySequence (biology)CascadeCombinatorial chemistryCatalysisBiochemistryChromatographyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsRadical Photochemical Reactions