Silencing KLK12 expression via RGDfC-decorated selenium nanoparticles for the treatment of colorectal cancer in vitro and in vivo
Yu Xia, Guoyi Tang, Min Guo, Tiantian Xu, Haiyang Chen, Zhengfang Lin, Yinghua Li, Yi Chen, Bing Zhu, Hongsheng Liu, Jie Cao
Topics & Concepts
Small interfering RNAGene silencingIn vivoEndocytosisIn vitroTransfectionCancer cellMaterials scienceApoptosisReactive oxygen speciesDownregulation and upregulationCell biologyCancer researchMolecular biologyCell cultureCancerBiologyCellBiochemistryGeneBiotechnologyGeneticsSelenium in Biological SystemsRNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery