A Narrative Review of Gut-Muscle Axis and Sarcopenia: The Potential Role of Gut Microbiota
Jiaxi Zhao, Yiqin Huang, Xiaofeng Yu
Abstract
Sarcopenia is a multifactorial disease related to aging, chronic inflammation, insufficient nutrition, and physical inactivity. Previous studies have suggested that there is a relationship between sarcopenia and gut microbiota,namely, the gut-muscle axis. The present review highlights that the gut microbiota can affect muscle mass and muscle function from inflammation and immunity,substance and energy metabolism, endocrine and insulin sensitivity, etc., directly or indirectly establishing a connection with sarcopenia, thereby realizing the "gut-muscle axis".
Topics & Concepts
SarcopeniaGut floraInflammationMedicineInsulin sensitivitySkeletal muscleEnergy metabolismImmunityNarrative reviewEndocrine systemBioinformaticsInsulin resistanceImmunologyImmune systemInternal medicineEndocrinologyDiabetes mellitusBiologyHormoneIntensive care medicineNutrition and Health in AgingDiet and metabolism studiesClinical Nutrition and Gastroenterology