Chronic perinatal hypoxia delays cardiac maturation in a mouse model for cyanotic congenital heart disease
Jennifer Romanowicz, Devon Guerrelli, Zaenab Dhari, Colm Mulvany, Marissa Reilly, Luther Swift, Nimisha Vasandani, Manelle Ramadan, Linda Leatherbury, Nobuyuki Ishibashi, Nikki Gillum Posnack
Abstract
We utilized a new mouse model of chronic perinatal hypoxia to simulate the hypoxic myocardial conditions present in cyanotic congenital heart disease. Hypoxia caused numerous abnormalities in cardiomyocyte gene expression, the electrophysiologic substrate of the heart, and contractile function. Taken together, alterations observed in the neonatal period suggest delayed cardiac development immediately following hypoxia.
Topics & Concepts
Hypoxia (environmental)Internal medicineCardiac function curveMedicineCardiologyHeart developmentHeart diseaseBradycardiaFetusPopulationBiologyHeart rateHeart failurePregnancyGeneOxygenBlood pressureEmbryonic stem cellOrganic chemistryGeneticsEnvironmental healthChemistryBiochemistryCongenital heart defects researchCongenital Heart Disease StudiesNeonatal and fetal brain pathology