A multifunctional anti-inflammatory drug that can specifically target activated macrophages, massively deplete intracellular H2O2, and produce large amounts CO for a highly efficient treatment of osteoarthritis
Guangzhen Yang, Mengni Fan, Jingwu Zhu, Ling Chen, Lihuang Wu, Xin Zhang, Ming Zhang, Jiayi Li, Qingqiang Yao, Zhongwei Gu, Xiaojun Cai
Topics & Concepts
Hyaluronic acidCell biologyProinflammatory cytokineMacrophageExtracellular matrixInflammationChemistryCancer researchPharmacologyBiochemistryBiologyIn vitroImmunologyGeneticsHeme Oxygenase-1 and Carbon MonoxideEicosanoids and Hypertension PharmacologyNanoplatforms for cancer theranostics