Reactivity of Viral Nucleic Acids with Chlorine and the Impact of Virus Encapsidation
Zhong Qiao, Yinyin Ye, Aleksandra Szczuka, Katherine R. Harrison, Michael C. Dodd, Krista R. Wigginton
Abstract
) that was 34×, 65×, and 189× lower than those of the dsRNA of φ6, ssRNA of MS2, and ssDNA of φX174, respectively. Moreover, different regions in the ssRNA genome of MS2 and the dsRNA genome of φ6 exhibited statistically different reaction kinetics. The genomes within virus particles reacted slower than the naked genomes overall, but the extent of these differences varied among the four viruses. The results on viral nucleic acid reactivity help explain different susceptibilities of viruses to inactivation by free chlorine and also provide a valuable comparison of the susceptibilities of different nucleic acids to oxidants.
Topics & Concepts
Nucleic acidGenomeVirusChlorineChemistryRNADNAPolymeraseBiologyVirologyReactivity (psychology)NucleotideBiochemistryGeneOrganic chemistryPathologyMedicineAlternative medicineViral gastroenteritis research and epidemiologyBacteriophages and microbial interactionsBacillus and Francisella bacterial research