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Functional characterization of a PROTAC directed against BRAF mutant V600E

Ganna Posternak, Xiaojing Tang, Pierre Maisonneuve, Ting Jin, Hugo Lavoie, Salima Daou, Stephen Orlicky, Théo Goullet de Rugy, Lauren Caldwell, Kin Chan, Ahmed Aman, Michaël Prakesch, Gennady Poda, P. Mäder, Cassandra J. Wong, Stefan Maier, Julia Kitaygorodsky, Brett Larsen, Karen Colwill, Zhe Yin, Derek F. Ceccarelli, Robert A. Batey, Mikko Taipale, Igor Kurinov, David Uehling, Jeffrey L. Wrana, Daniel Durocher, Anne‐Claude Gingras, Rima Al‐awar, Marc Therrien, Frank Sicheri

2020Nature Chemical Biology131 citationsDOIOpen Access PDF

Topics & Concepts

MAPK/ERK pathwayKinaseMutantCancer researchV600EProteolysisCell growthMutationHEK 293 cellsSynthetic lethalityCell cultureCell biologyBiologyGeneticsBiochemistryEnzymeGeneProtein Degradation and InhibitorsMelanoma and MAPK PathwaysUbiquitin and proteasome pathways
Functional characterization of a PROTAC directed against BRAF mutant V600E | Litcius