First total synthesis of chromanone A, preparation of related compounds and evaluation of their antifungal activity against<i>Candida albicans</i>, a biofilm forming agent
Iván Cortés, Estefanía Cordisco, Teodoro S. Kaufman, Maximiliano Sortino, Laura Svetaz, Andrea B. J. Bracca
Abstract
Chromanone A and its 7-OMe analogue were totally synthesized. 2-Formyl chromanone A derivative inhibited<italic>C. albicans</italic>and its virulence factors.
Topics & Concepts
Candida albicansAntifungalBiofilmCorpus albicansVirulenceMicrobiologyDerivative (finance)ChemistryBiologyBacteriaBiochemistryEconomicsFinancial economicsGeneticsGeneMarine Sponges and Natural ProductsSynthesis of Organic CompoundsMicrobial Natural Products and Biosynthesis