Biomimetic Inorganic Nanoparticle-Loaded Silk Fibroin-Based Coating with Enhanced Antibacterial and Osteogenic Abilities
Yunpeng Zhang, Xiaorong Chen, Yuan Li, Tian Bai, Chen Li, Lingyan Jiang, Yu Liu, Changying Sun, Wenhao Zhou
Abstract
cell experiments revealed that the biomimetic silk fibroin-based coating was beneficial to the adhesion, spreading, and proliferation of osteoblasts (MC3T3-E1). In addition, by characterizing LDH and ROS, it was found that the nHA/Ag complex could significantly reduce the cytotoxicity of AgNPs, and the osteoblasts on the coating surface maintained the structure intact.
Topics & Concepts
FibroinCoatingOsseointegrationMaterials scienceSilver nanoparticleSILKAdhesionNanoparticleTransmission electron microscopyNanotechnologyChemistryChemical engineeringComposite materialImplantMedicineEngineeringSurgeryBone Tissue Engineering MaterialsSilk-based biomaterials and applicationsPeriodontal Regeneration and Treatments