Harnessing biological insights to accelerate drug discovery against ESKAPE pathogens
Tashi Palmo, Vishwani Jamwal, Diksha Kumari, Kuljit Singh
Abstract
infection models have been explored that pave the way for unraveling novel therapies against a wide spectrum of ESKAPE pathogens. Lastly, this review delves into the significant challenges faced by the research community in the drug discovery process and explores potential avenues to combat the growing threat of drug-resistant pathogens.
Topics & Concepts
Drug discoveryEffluxDrug resistanceAntibiotic resistanceAntimicrobialDrugComputational biologyAntibioticsPorinBiologyAntimicrobial drugBacteriaHuman healthDrug developmentMicrobiologyMedicineImmune systemAnti-Infective AgentsHost (biology)Global healthBioinformaticsAntibiotic Resistance in BacteriaAntimicrobial Peptides and ActivitiesPhenothiazines and Benzothiazines Synthesis and Activities