Mitochondrial Calcium Uniporter Affects Neutrophil Bactericidal Activity during Staphylococcus aureus Infection
Andrew J. Monteith, Jeanette M. Miller, William N. Beavers, K. Nichole Maloney, Erin L. Seifert, György Hajnóczky, Eric P. Skaar
Abstract
Neutrophils simultaneously restrict Staphylococcus aureus dissemination and facilitate bactericidal activity during infection through the formation of neutrophil extracellular traps (NETs). Neutrophils that produce higher levels of mitochondrial superoxide undergo enhanced terminal NET formation (suicidal NETosis) in response to S. aureus ; however, mechanisms regulating mitochondrial homeostasis upstream of neutrophil antibacterial processes are not fully resolved.
Topics & Concepts
Staphylococcus aureusMicrobiologyBiologyCalciumUniporterStaphylococcal infectionsBacteriaBiochemistryChemistryEnzymeOrganic chemistryCytosolGeneticsNeutrophil, Myeloperoxidase and Oxidative MechanismsAntimicrobial Resistance in StaphylococcusTrace Elements in Health